{"entity": "journal", "iuid": "0a8fef4905854955ae99a69235106004", "timestamp": "2026-08-09T07:25:21.697Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Chemosphere.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Chemosphere"}}, "title": "Chemosphere", "issn": "1879-1298", "issn-l": "0045-6535", "publications_count": 8, "publications": [{"entity": "publication", "iuid": "c03c4c5c56a14045971dc3d0630bfac5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c03c4c5c56a14045971dc3d0630bfac5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c03c4c5c56a14045971dc3d0630bfac5"}}, "title": "Persistent effects of di-n-butyl phthalate on liver transcriptome: impaired energy and lipid metabolic pathways.", "authors": [{"family": "Theodoropoulou", "given": "Eleftheria", "initials": "E"}, {"family": "Pierozan", "given": "Paula", "initials": "P"}, {"family": "Marabita", "given": "Francesco", "initials": "F"}, {"family": "H\u00f6glund", "given": "Andrey", "initials": "A"}, {"family": "Karlsson", "given": "Oskar", "initials": "O"}], "type": "journal article", "published": "2024-10-21", "journal": {"title": "Chemosphere", "issn": "1879-1298", "pages": "143605", "issn-l": "0045-6535"}, "abstract": "The environmental contaminant dibutyl phthalate (DBP) is reported to be hepatotoxic, but the underlying molecular pathways and pathological processes remain unclear. Here we used RNA-sequencing to characterize persistent hepatic transcriptional effects one week after the conclusion of five weeks oral exposure to 10 mg/kg/day or 100 mg/kg/day DBP in male mice. The exploratory transcriptome analysis demonstrated five differentially expressed genes (DEGs) in the 10 mg/kg/day group and thirteen in the 100 mg/kg/day group. Gene Set Enrichment Analysis (GSEA), which identifies affected biological pathways rather than focusing solely on individual genes, revealed nine significantly enriched Reactome pathways shared by both DBP treatment groups. Additionally, we found 54 upregulated and one downregulated Reactome pathways in the 10 mg/kg/day DBP group, and 29 upregulated and 13 downregulated pathways in the 100 mg/kg/day DBP group. According to the DEGs and the GSEA findings DBP exposure disrupts several key biological processes, including protein translation, protein folding, apoptosis, hedgehog signaling, degradation of extracellular matrix and alterations in the energy/lipid metabolism. Subsequent liver tissue analysis corroborated these findings, showing that DBP exposure induced tissue disorganization, oxidative stress, lipid accumulation, increased TNF-\u03b1, ATP and glucokinase levels. In addition, several proteins central for the metabolic system were affected, mostly in a dose-response pattern. Taken together the results show that DBP can cause hepatic stress and damage and suggest a potential role for DBP in the development of non-alcoholic fat liver disease, the most prevalent liver disease worldwide.", "doi": "10.1016/j.chemosphere.2024.143605", "pmid": "39442571", "labels": {"NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "NGI Short read": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0045-6535(24)02505-0"}], "notes": [], "created": "2024-10-31T12:34:26.795Z", "modified": "2024-11-25T10:12:32.978Z"}, {"entity": "publication", "iuid": "5844a2f4852440a48e31f579db10b691", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5844a2f4852440a48e31f579db10b691.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5844a2f4852440a48e31f579db10b691"}}, "title": "Chemical composition and species identification of microalgal biomass grown at pilot-scale with municipal wastewater and CO2 from flue gases.", "authors": [{"family": "Lage", "given": "Sandra", "initials": "S"}, {"family": "Gentili", "given": "Francesco G", "initials": "FG"}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Chemosphere", "issn": "1879-1298", "volume": "313", "pages": "137344", "issn-l": "0045-6535"}, "abstract": "The production potential of a locally isolated Chlorella vulgaris strain and a local green-algae consortium, used in municipal wastewater treatment combined with CO2 sequestration from flue gases, was evaluated for the first time by comparing the elemental and biochemical composition and heating value of the biomass produced. The microalgae were grown in outdoor pilot-scale ponds under subarctic summer conditions. The impact of cultivation in a greenhouse climate was also tested for the green-algae consortium; additionally, the variation in species composition over time in the three ponds was investigated. Our results showed that the biomass produced in the consortium/outdoor pond had the greatest potential for bioenergy production because both its carbohydrates and lipids contents were significantly higher than the biomasses from the consortium/greenhouse and C. vulgaris/outdoor ponds. Although greenhouse conditions significantly increased the consortium biomass's monounsaturated fatty acid content, which is ideal for biodiesel production, an undesirable increase in ash and chemical elements, as well as a reduction in heating value, were also observed. Thus, the placement of the pond inside a greenhouse did not improve the production potential of the green-algae consortium biomass in the current study infrastructure and climate conditions.", "doi": "10.1016/j.chemosphere.2022.137344", "pmid": "36457266", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "S0045-6535(22)03837-1"}], "notes": [], "created": "2023-08-30T07:08:56.122Z", "modified": "2025-10-17T13:03:14.400Z"}, {"entity": "publication", "iuid": "7ec8ad599b244aa380dd793cff5e96d7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/7ec8ad599b244aa380dd793cff5e96d7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/7ec8ad599b244aa380dd793cff5e96d7"}}, "title": "Effects of conventionally treated and ozonated wastewater on the damselfly larva oxylipidome in response to on-site exposure.", "authors": [{"family": "Sp\u00e4th", "given": "Jana", "initials": "J"}, {"family": "Brodin", "given": "Tomas", "initials": "T"}, {"family": "Fal\u00e5s", "given": "Per", "initials": "P"}, {"family": "Niinipuu", "given": "Mirva", "initials": "M"}, {"family": "Lindberg", "given": "Richard", "initials": "R"}, {"family": "Fick", "given": "Jerker", "initials": "J"}, {"family": "Nording", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2022-12-00", "journal": {"title": "Chemosphere", "issn": "1879-1298", "volume": "309", "issue": "Pt 1", "pages": "136604", "issn-l": "0045-6535"}, "abstract": "Pharmaceutical residues discharged through insufficiently treated or untreated wastewater enter aquatic environments, where they may adversely impact organisms such as aquatic invertebrates. Ozonation, an advanced wastewater treatment technique, has been successfully implemented to enhance the removal of a broad range of pharmaceuticals, however diverse byproducts and transformation products that are formed during the ozonation process make it difficult to predict how ozonated wastewater may affect aquatic biota. The aim of this study was to investigate effects on fatty acid metabolites, oxylipins, in a common invertebrate species, damselfly larvae, after on-site exposure to conventional wastewater treatment plant (WWTP) effluent and additionally ozonated effluent at a full-scale WWTP. Subsequent ozonation of the conventionally treated wastewater was assessed in terms of i) removal of pharmaceuticals and ii) potential sub-lethal effects on the oxylipidome. Northern damselfly (Coenagrion hastulatum) larvae were exposed for six days in the treatment plant facility to either conventional WWTP effluent or ozonated effluent and the effects on pharmaceutical levels and oxylipin levels were compared with those from tap water control exposure. Ozonation removed pharmaceuticals at an average removal efficiency of 67% (ozone dose of 0.49 g O3/g DOC). Of 38 pharmaceuticals detected in the effluent, 16 were removed to levels below the limit of quantification by ozonation. Levels of two oxylipins, 12(13)-EpODE and 15(16)-EpODE, were reduced in larvae exposed to the conventionally treated wastewater in comparison to the tap water control. 15(16)-EpODE was reduced in the larvae exposed to ozonated effluent in comparison to the tap water control. One oxylipin, 8-HETE, was significantly lower in larvae exposed to conventional WWTP effluent compared to ozonated effluent. In conclusion, the study provides proof-of-principle that damselfly larvae can be used on-site to test the impact of differentially treated wastewater.", "doi": "10.1016/j.chemosphere.2022.136604", "pmid": "36179924", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "S0045-6535(22)03097-1"}], "notes": [], "created": "2022-12-05T08:14:00.029Z", "modified": "2025-10-17T13:03:14.520Z"}, {"entity": "publication", "iuid": "034f6544dc3b4fbfb4aa2a0f67d8bcc3", "links": {"self": {"href": "https://publications.scilifelab.se/publication/034f6544dc3b4fbfb4aa2a0f67d8bcc3.json"}, "display": {"href": "https://publications.scilifelab.se/publication/034f6544dc3b4fbfb4aa2a0f67d8bcc3"}}, "title": "Human adaptation to arsenic in Bolivians living in the Andes.", "authors": [{"family": "De Loma", "given": "Jessica", "initials": "J"}, {"family": "Vicente", "given": "M\u00e1rio", "initials": "M"}, {"family": "Tirado", "given": "Noemi", "initials": "N"}, {"family": "Ascui", "given": "Franz", "initials": "F"}, {"family": "Vahter", "given": "Marie", "initials": "M"}, {"family": "Gardon", "given": "Jacques", "initials": "J"}, {"family": "Schlebusch", "given": "Carina M", "initials": "CM"}, {"family": "Broberg", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Chemosphere", "issn": "1879-1298", "volume": "301", "pages": "134764", "issn-l": "0045-6535"}, "abstract": "Humans living in the Andes Mountains have been historically exposed to arsenic from natural sources, including drinking water. Enzymatic methylation of arsenic allows it to be excreted more efficiently by the human body. Adaptation to high-arsenic environments via enhanced methylation and excretion of arsenic was first reported in indigenous women in the Argentinean Andes, but whether adaptation to arsenic is a general phenomenon across native populations from the Andes Mountains remains unclear. Therefore, we evaluated whether adaptation to arsenic has occurred in the Bolivian Andes by studying indigenous groups who belong to the Aymara-Quechua and Uru ethnicities and have lived in the Bolivian Andes for generations. Our population genetics methods, including genome-wide selection scans based on linkage disequilibrium patterns and allele frequency differences, in combination with targeted and whole-genome sequencing and genotype-phenotype association analyses, detected signatures of positive selection near the gene encoding arsenite methyltransferase (AS3MT), the main arsenic methylating enzyme. This was among the strongest selection signals (top 0.5% signals via locus-specific branch length and extended haplotype homozygosity tests) at a genome-wide level in the Bolivian study groups. We found a large haplotype block of 676 kb in the AS3MT region and identified candidate functional variants for further analysis. Moreover, our analyses revealed associations between AS3MT variants and the fraction of mono-methylated arsenic in urine and showed that the Bolivian study groups had the highest frequency of alleles associated with more efficient arsenic metabolism reported so far. Our data support the idea that arsenic exposure has been a driver for human adaptation to tolerate arsenic through more efficient arsenic detoxification in different Andean populations.", "doi": "10.1016/j.chemosphere.2022.134764", "pmid": "35490756", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support and Infrastructure": "Service", "NGI Long read": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service"}, "xrefs": [{"db": "pii", "key": "S0045-6535(22)01257-7"}], "notes": [], "created": "2022-06-14T13:16:20.200Z", "modified": "2024-01-16T13:48:35.529Z"}, {"entity": "publication", "iuid": "651d366697f94c158cceed4a8a30e8c8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/651d366697f94c158cceed4a8a30e8c8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/651d366697f94c158cceed4a8a30e8c8"}}, "title": "Increased apoptosis, reduced Wnt/\u03b2-catenin signaling, and altered tail development in zebrafish embryos exposed to a human-relevant chemical mixture.", "authors": [{"family": "Smirnova", "given": "Anna", "initials": "A", "orcid": "0000-0001-5512-2214", "researcher": {"href": "https://publications.scilifelab.se/researcher/ea2c701706d547718d2274eb5d00ffa2.json"}}, {"family": "Mentor", "given": "Anna", "initials": "A", "orcid": "0000-0002-7389-8849", "researcher": {"href": "https://publications.scilifelab.se/researcher/a9f81325ea6d49afb632bfbbeb3cdfa4.json"}}, {"family": "Ranefall", "given": "Petter", "initials": "P", "orcid": "0000-0002-6699-4015", "researcher": {"href": "https://publications.scilifelab.se/researcher/4332883c0058421f8dfb85406ec03524.json"}}, {"family": "Bornehag", "given": "Carl-Gustaf", "initials": "C"}, {"family": "Brunstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Mattsson", "given": "Anna", "initials": "A"}, {"family": "J\u00f6nsson", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Chemosphere", "issn": "1879-1298", "issn-l": "0045-6535", "volume": "264", "issue": "1", "pages": "128467"}, "abstract": "A wide variety of anthropogenic chemicals is detected in humans and wildlife and the health effects of various chemical exposures are not well understood. Early life stages are generally the most susceptible to chemical disruption and developmental exposure can cause disease in adulthood, but the mechanistic understanding of such effects is poor. Within the EU project EDC-MixRisk, a chemical mixture (Mixture G) was identified in the Swedish pregnancy cohort SELMA by the inverse association between levels in women at around gestational week ten with birth weight of their children. This mixture was composed of mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-ethylhexyl phthalate, mono-isononyl phthalate, triclosan, perfluorohexane sulfonate, perfluorooctanoic acid, and perfluorooctane sulfonate. In a series of experimental studies, we characterized effects of Mixture G on early development in zebrafish models. Here, we studied apoptosis and Wnt/\u03b2-catenin signaling which are two evolutionarily conserved signaling pathways of crucial importance during development. We determined effects on apoptosis by measuring TUNEL staining, caspase-3 activity, and acridine orange staining in wildtype zebrafish embryos, while Wnt/\u03b2-catenin signaling was assayed using a transgenic line expressing an EGFP reporter at \u03b2-catenin-regulated promoters. We found that Mixture G increased apoptosis, suppressed Wnt/\u03b2-catenin signaling in the caudal fin, and altered the shape of the caudal fin at water concentrations only 20-100 times higher than the geometric mean serum concentration in the human cohort. These findings call for awareness that pollutant mixtures like mixture G may interfere with a variety of developmental processes, possibly resulting in adverse health effects.", "doi": "10.1016/j.chemosphere.2020.128467", "pmid": "33032226", "labels": {"BioImage Informatics": "Collaborative", "Genome Engineering Zebrafish": "Service", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0045-6535(20)32662-X"}], "notes": [], "created": "2020-11-09T12:03:44.888Z", "modified": "2021-11-29T12:55:27.213Z"}, {"entity": "publication", "iuid": "e78f5c80e0f7468e9c635acda6db895d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e78f5c80e0f7468e9c635acda6db895d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e78f5c80e0f7468e9c635acda6db895d"}}, "title": "Activated carbon stimulates microbial diversity and PAH biodegradation under anaerobic conditions in oil-polluted sediments.", "authors": [{"family": "Bonaglia", "given": "Stefano", "initials": "S", "orcid": "0000-0003-4366-0677", "researcher": {"href": "https://publications.scilifelab.se/researcher/c02dd99f9fd14dd89d5c231260806720.json"}}, {"family": "Broman", "given": "Elias", "initials": "E", "orcid": "0000-0001-9005-5168", "researcher": {"href": "https://publications.scilifelab.se/researcher/63826da04a1f4f80bc3229df12bac9b7.json"}}, {"family": "Brindefalk", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Hedlund", "given": "Erika", "initials": "E"}, {"family": "Hjorth", "given": "Tomas", "initials": "T"}, {"family": "Rolff", "given": "Carl", "initials": "C"}, {"family": "Nascimento", "given": "Francisco J A", "initials": "FJA"}, {"family": "Udekwu", "given": "Klas", "initials": "K"}, {"family": "Gunnarsson", "given": "Jonas S", "initials": "JS"}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Chemosphere", "issn": "1879-1298", "volume": "248", "issue": null, "pages": "126023", "issn-l": "0045-6535"}, "abstract": "Biodegradation by microorganisms is a useful tool that helps alleviating hydrocarbon pollution in nature. Microbes are more efficient in degradation under aerobic than anaerobic conditions, but the majority of sediment by volume is generally anoxic. Incubation experiments were conducted to study the biodegradation potential of naphthalene-a common polycyclic aromatic hydrocarbon (PAH)-and the diversity of microbial communities in presence/absence of activated carbon (AC) under aerobic/anaerobic conditions. Radio-respirometry experiments with endogenous microorganisms indicated that degradation of naphthalene was strongly stimulated (96%) by the AC addition under anaerobic conditions. In aerobic conditions, however, AC had no effects on naphthalene biodegradation. Bioaugmentation tests with cultured microbial populations grown on naphthalene showed that AC further stimulated (92%) naphthalene degradation in anoxia. Analysis of the 16S rRNA gene sequences implied that sediment amendment with AC increased microbial community diversity and changed community structure. Moreover, the relative abundance of Geobacter, Thiobacillus, Sulfuricurvum, and methanogenic archaea increased sharply after amendment with AC under anaerobic conditions. These results may be explained by the fact that AC particles promoted direct interspecies electron transfer (DIET) between microorganisms involved in PAH degradation pathways. We suggest that important ecosystem functions mediated by microbes-such as hydrocarbon degradation-can be induced and that AC enrichment strategies can be exploited for facilitating bioremediation of anoxic oil-contaminated sediments and soils.", "doi": "10.1016/j.chemosphere.2020.126023", "pmid": "32007777", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "S0045-6535(20)30216-2"}], "notes": [], "created": "2020-07-08T13:03:41.428Z", "modified": "2024-01-16T13:48:42.467Z"}, {"entity": "publication", "iuid": "4a530cc078974c2fa521cfd52618150b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/4a530cc078974c2fa521cfd52618150b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/4a530cc078974c2fa521cfd52618150b"}}, "title": "Developmental exposure to a human relevant mixture of endocrine disruptors alters metabolism and adipogenesis in zebrafish (Danio rerio).", "authors": [{"family": "Mentor", "given": "Anna", "initials": "A", "orcid": "0000-0002-7389-8849", "researcher": {"href": "https://publications.scilifelab.se/researcher/a9f81325ea6d49afb632bfbbeb3cdfa4.json"}}, {"family": "Brunstr\u00f6m", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Mattsson", "given": "Anna", "initials": "A", "orcid": "0000-0002-5328-6255", "researcher": {"href": "https://publications.scilifelab.se/researcher/e317be04e29a4448a0275e38dd7b0d52.json"}}, {"family": "J\u00f6nsson", "given": "Maria", "initials": "M"}], "type": "journal article", "published": "2020-01-00", "journal": {"title": "Chemosphere", "issn": "1879-1298", "volume": "238", "issue": null, "pages": "124584", "issn-l": "0045-6535"}, "abstract": "Exposure to endocrine disrupting chemicals has been suggested to contribute to the ongoing globally increasing obesity trend. The complex chemical mixtures that humans and wildlife are exposed to include a number of compounds that may have obesogenic properties. In this study we examined a mixture consisting of phthalate-monoesters, triclosan, and perfluorinated compounds. The mixture was designed within the EDC-MixRisk project based on serum levels of the compounds in pregnant women of a Swedish mother-child cohort. The compounds were negatively associated with birth weight of the children. We assessed whether developmental exposure to this mixture in combination with a calorie-rich diet affected metabolic rate, blood lipids, adipogenesis and lipid storage, and the whole-body level of neutral lipids in zebrafish (Danio rerio). Wildtype zebrafish were exposed to the mixture from 3 h post fertilization to 5, 14 or 17 days post fertilization (dpf) at water concentrations corresponding to 1, 10, 20, or 100 times the geometrical mean of the serum concentration (hsc) in the women. Exposure to the mixture at 20 times hsc lowered metabolic rate at 2-5 dpf, and increased the number of adipocytes and the amount of visceral adipose tissue at 14 and 17 dpf respectively. Also, mRNA expression of fatty acid binding protein 11a was increased at 17 dpf by 10 and 20 times hsc of the mixture. This study shows that a human-relevant mixture of environmental pollutants affects metabolic rate, adipogenesis and lipid storage in young zebrafish fed a calorie-rich diet, thus demonstrating its potential to disrupt metabolism.", "doi": "10.1016/j.chemosphere.2019.124584", "pmid": "31470313", "labels": {"Genome Engineering Zebrafish": "Service"}, "xrefs": [{"db": "pii", "key": "S0045-6535(19)31808-9"}], "notes": [], "created": "2019-12-02T13:30:04.858Z", "modified": "2021-11-10T12:55:34.802Z"}, {"entity": "publication", "iuid": "0ec683f8f7684da99ee7630c86c5afc2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0ec683f8f7684da99ee7630c86c5afc2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0ec683f8f7684da99ee7630c86c5afc2"}}, "title": "Pretreatment of anaerobic digester samples by hydrochloric acid for solution-state 1 H and 13 C NMR spectroscopic characterization of organic matter", "authors": [{"family": "Shakeri Yekta", "given": "Sepehr", "initials": "S"}, {"family": "Hedenstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Stehr", "given": "Jan Eric", "initials": "JE"}, {"family": "Dario", "given": "M\u00e5rten", "initials": "M"}, {"family": "Hertkorn", "given": "Norbert", "initials": "N"}, {"family": "Bj\u00f6rn", "given": "Annika", "initials": "A"}], "type": "journal-article", "published": "2018-05-00", "journal": {"volume": "199", "issn": "0045-6535", "issue": null, "pages": "201-209", "title": "Chemosphere", "issn-l": null}, "abstract": null, "doi": "10.1016/j.chemosphere.2018.02.015", "pmid": "29438947", "labels": {"Swedish NMR Centre": "Collaborative"}, "xrefs": [], "notes": [], "created": "2018-10-22T11:18:17.070Z", "modified": "2025-10-17T13:03:58.782Z"}], "created": "2018-10-22T11:18:17.078Z", "modified": "2020-11-27T13:14:07.922Z"}