{"entity": "journal", "iuid": "0e19bae84d9448daad496f43f43f0eac", "timestamp": "2026-07-15T16:30:49.581Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Chem.%20Commun.%20%28Camb.%29.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Chem.%20Commun.%20%28Camb.%29"}}, "title": "Chem. Commun. (Camb.)", "issn": "1364-548X", "issn-l": "1359-7345", "publications_count": 7, "publications": [{"entity": "publication", "iuid": "2a366cbffd9d403f89718e65c9e2b1a0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2a366cbffd9d403f89718e65c9e2b1a0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2a366cbffd9d403f89718e65c9e2b1a0"}}, "title": "Hydrazide-based reactive matrices for the sensitive detection of aldehydes and ketones by MALDI mass spectrometry imaging.", "authors": [{"family": "Lod\u00e9n", "given": "Henrik", "initials": "H", "orcid": "0000-0002-2416-5251", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd5349a708e242769091df471639f5b6.json"}}, {"family": "Schembri", "given": "Luke S", "initials": "LS", "orcid": "0000-0001-5588-1077", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dc760b581324125816ed40eb748104c.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Kaya", "given": "Ibrahim", "initials": "I"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R"}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications.scilifelab.se/researcher/7653ba79ce9d4e4a80be4b42f516680b.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications.scilifelab.se/researcher/64f6381de42949db8d30b56b526f3e26.json"}}], "type": "journal article", "published": "2024-08-22", "journal": {"title": "Chem. Commun. (Camb.)", "issn": "1364-548X", "volume": "60", "issue": "69", "pages": "9238-9241", "issn-l": "1359-7345"}, "abstract": "A one-step, on-tissue chemical derivatisation method for MALDI mass spectrometry imaging was found to improve the detectability of aldehydes and ketones by charge-tagging. The developed reactive matrices, containing a UV-chromophore, ionisable moiety and hydrazide group, showed an equal or higher detection efficiency than Girard's reagent P, enabling improved imaging of brain metabolites without the need for additional co-matrices.", "doi": "10.1039/d4cc02475c", "pmid": "39114958", "labels": {"Spatial Mass Spectrometry": "Technology development"}, "xrefs": [], "notes": [], "created": "2024-11-20T10:38:02.805Z", "modified": "2024-11-20T10:40:23.399Z"}, {"entity": "publication", "iuid": "2d0ca3bc4bb74317b4b1fd76a9ca3a0c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2d0ca3bc4bb74317b4b1fd76a9ca3a0c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2d0ca3bc4bb74317b4b1fd76a9ca3a0c"}}, "title": "Resolution enhancement of NMR by decoupling with the low-rank Hankel model.", "authors": [{"family": "Qiu", "given": "Tianyu", "initials": "T", "orcid": "0000-0002-6102-8627", "researcher": {"href": "https://publications.scilifelab.se/researcher/c8230b09d4c0478f8deaed3a8b384b94.json"}}, {"family": "Jahangiri", "given": "Amir", "initials": "A", "orcid": "0000-0001-6051-3738", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5925aa696864034a668230fb68d91bf.json"}}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Lesovoy", "given": "Dmitry", "initials": "D"}, {"family": "Agback", "given": "Tatiana", "initials": "T", "orcid": "0000-0003-1325-6024", "researcher": {"href": "https://publications.scilifelab.se/researcher/8ded0891ca3d4bdda4082ffa347ca37a.json"}}, {"family": "Agback", "given": "Peter", "initials": "P"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications.scilifelab.se/researcher/39682601d1a24f5ba1d103bf74c9acbd.json"}}, {"family": "Qu", "given": "Xiaobo", "initials": "X", "orcid": "0000-0002-0863-2454", "researcher": {"href": "https://publications.scilifelab.se/researcher/e450c06cfb6d4ff3847e5d98dc818d2b.json"}}, {"family": "Orekhov", "given": "Vladislav", "initials": "V", "orcid": "0000-0002-7892-6896", "researcher": {"href": "https://publications.scilifelab.se/researcher/77382c412de04fa08ff7c3bc7087b77e.json"}}], "type": "journal article", "published": "2023-05-02", "journal": {"title": "Chem. Commun. (Camb.)", "issn": "1364-548X", "issn-l": "1359-7345", "volume": "59", "issue": "36", "pages": "5475-5478"}, "abstract": "Nuclear magnetic resonance (NMR) spectroscopy has become a formidable tool for biochemistry and medicine. Although J-coupling carries essential structural information it may also limit the spectral resolution. Homonuclear decoupling remains a challenging problem. In this work, we introduce a new approach that uses a specific coupling value as prior knowledge, and the Hankel property of the exponential NMR signal to achieve broadband heteronuclear decoupling using the low-rank method. Our results on synthetic and realistic HMQC spectra demonstrate that the proposed method not only effectively enhances resolution by decoupling, but also maintains sensitivity and suppresses spectral artefacts. The approach can be combined with non-uniform sampling, which means that the resolution can be further improved without any extra acquisition time.", "doi": "10.1039/d2cc06682c", "pmid": "37070867", "labels": {"Swedish NMR Centre": "Technology development"}, "xrefs": [{"db": "pmc", "key": "PMC10152455"}], "notes": [], "created": "2023-05-31T16:37:33.329Z", "modified": "2025-10-17T13:03:53.921Z"}, {"entity": "publication", "iuid": "e3d59e32739d4f7e93ec76c6f809a20d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e3d59e32739d4f7e93ec76c6f809a20d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e3d59e32739d4f7e93ec76c6f809a20d"}}, "title": "Design and development of a photoswitchable DFG-out kinase inhibitor.", "authors": [{"family": "Xu", "given": "Yongjin", "initials": "Y"}, {"family": "Gao", "given": "Chunxia", "initials": "C"}, {"family": "H\u00e5versen", "given": "Liliana", "initials": "L"}, {"family": "Lundb\u00e4ck", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8145-7808", "researcher": {"href": "https://publications.scilifelab.se/researcher/e13df787cb884549bcf333aba4e6f010.json"}}, {"family": "Andr\u00e9asson", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4695-7943", "researcher": {"href": "https://publications.scilifelab.se/researcher/28eb5affb5664c54be9171dfce6bea15.json"}}, {"family": "Gr\u00f8tli", "given": "Morten", "initials": "M", "orcid": "0000-0003-3621-4222", "researcher": {"href": "https://publications.scilifelab.se/researcher/764706606bcb4afba1150af332c0f124.json"}}], "type": "journal article", "published": "2021-09-30", "journal": {"title": "Chem. Commun. (Camb.)", "issn": "1364-548X", "issn-l": "1359-7345", "volume": "57", "issue": "78", "pages": "10043-10046"}, "abstract": "We report the synthesis and characterisation of a photoswitchable DFG-out kinase inhibitor. Photocontrol of the target kinase in both enzymatic and living cell assays is demonstrated.", "doi": "10.1039/d1cc04125h", "pmid": "34505602", "labels": {"Chemical Biology Consortium Sweden": "Service"}, "xrefs": [], "notes": [], "created": "2021-11-03T11:52:31.970Z", "modified": "2025-10-17T13:04:28.037Z"}, {"entity": "publication", "iuid": "ed9dfb96ce7b4525960909d2a2186e16", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ed9dfb96ce7b4525960909d2a2186e16.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ed9dfb96ce7b4525960909d2a2186e16"}}, "title": "Resolution enhancement in NMR spectra by deconvolution with compressed sensing reconstruction.", "authors": [{"family": "Kazimierczuk", "given": "Krzysztof", "initials": "K", "orcid": "0000-0001-9585-1737", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad35e5f050384e6c94bc2d06066a1cf6.json"}}, {"family": "Kasprzak", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0001-7387-4284", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa6e68d3b1d442efb5418ee75f8f54d0.json"}}, {"family": "Georgoulia", "given": "Panagiota S", "initials": "PS", "orcid": "0000-0003-4573-8052", "researcher": {"href": "https://publications.scilifelab.se/researcher/419e2b2c66404881b3e7a51dbd47fcdb.json"}}, {"family": "Mate\u010dko-Burmann", "given": "Irena", "initials": "I", "orcid": "0000-0001-8873-8381", "researcher": {"href": "https://publications.scilifelab.se/researcher/b8f4fca92f6143aea4378e5e081339ca.json"}}, {"family": "Burmann", "given": "Bj\u00f6rn M", "initials": "BM", "orcid": "0000-0002-3135-7964", "researcher": {"href": "https://publications.scilifelab.se/researcher/b7a6d61fc1a64677874973c3247b1eb4.json"}}, {"family": "Isaksson", "given": "Linn\u00e9a", "initials": "L"}, {"family": "Gustavsson", "given": "Emil", "initials": "E", "orcid": "0000-0003-0166-1786", "researcher": {"href": "https://publications.scilifelab.se/researcher/474b967a7726414288142c12b7b9dc3f.json"}}, {"family": "Westenhoff", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-6961-8015", "researcher": {"href": "https://publications.scilifelab.se/researcher/3f1519bb234b43c6a13833b04e6720b8.json"}}, {"family": "Orekhov", "given": "Vladislav Yu", "initials": "VY", "orcid": "0000-0002-7892-6896", "researcher": {"href": "https://publications.scilifelab.se/researcher/77382c412de04fa08ff7c3bc7087b77e.json"}}], "type": "journal article", "published": "2020-12-04", "journal": {"title": "Chem. Commun. (Camb.)", "issn": "1364-548X", "volume": "56", "issue": "93", "pages": "14585-14588", "issn-l": "1359-7345"}, "abstract": "NMR spectroscopy is one of the basic tools for molecular structure elucidation. Unfortunately, the resolution of the spectra is often limited by inter-nuclear couplings. The existing workarounds often alleviate the problem by trading it for another deficiency, such as spectral artefacts or difficult sample preparation and, thus, are rarely used. We suggest an approach using the coupling deconvolution in the framework of compressed sensing (CS) spectra processing that leads to a major increase in resolution, sensitivity, and overall quality of NUS reconstruction. A new mathematical description of the decoupling by deconvolution explains the effects of thermal noise and reveals a relation with the underlying assumption of the CS. The gain in resolution and sensitivity for challenging molecular systems is demonstrated for the key HNCA experiment used for protein backbone assignment applied to two large proteins: intrinsically disordered 441-residue Tau and a 509-residue globular bacteriophytochrome fragment. The approach will be valuable in a multitude of chemistry applications, where NMR experiments are compromised by the homonuclear scalar coupling.", "doi": "10.1039/d0cc06188c", "pmid": "33146166", "labels": {"Swedish NMR Centre": "Collaborative"}, "xrefs": [], "notes": [], "created": "2020-12-11T09:16:11.124Z", "modified": "2025-10-17T13:03:56.405Z"}, {"entity": "publication", "iuid": "873a9cb74fa049cb8f2b0f1a71974f91", "links": {"self": {"href": "https://publications.scilifelab.se/publication/873a9cb74fa049cb8f2b0f1a71974f91.json"}, "display": {"href": "https://publications.scilifelab.se/publication/873a9cb74fa049cb8f2b0f1a71974f91"}}, "title": "Cobalt-doped hematite thin films for electrocatalytic water oxidation in highly acidic media.", "authors": [{"family": "Kwong", "given": "Wai Ling", "initials": "WL", "orcid": "0000-0002-9732-8867", "researcher": {"href": "https://publications.scilifelab.se/researcher/e772338c26bd48e5a50e333e8687b80d.json"}}, {"family": "Lee", "given": "Cheng Choo", "initials": "CC"}, {"family": "Shchukarev", "given": "Andrey", "initials": "A"}, {"family": "Messinger", "given": "Johannes", "initials": "J", "orcid": "0000-0003-2790-7721", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d8388d9249849f4b45d7a891c71c0ff.json"}}], "type": "journal article", "published": "2019-04-23", "journal": {"volume": "55", "issn": "1364-548X", "issue": "34", "pages": "5017-5020", "title": "Chem. Commun. (Camb.)", "issn-l": "1359-7345"}, "abstract": "Earth-abundant cobalt-doped hematite thin-film electrocatalysts were explored for acidic water oxidation. The strategically doped hematite produced a stable geometric current density of 10 mA cm-2 for up to 50 h at pH 0.3, as a result of Co-enhanced intrinsic catalytic activity and charge transport properties across the film matrix.", "doi": "10.1039/c9cc01369e", "pmid": "30968887", "labels": {"Integrated Microscopy Technologies Ume\u00e5": "Collaborative"}, "xrefs": [], "notes": [], "created": "2020-02-12T14:26:11.880Z", "modified": "2021-06-21T13:48:09.399Z"}, {"entity": "publication", "iuid": "77da5ef1c8c94bc48cce4fe25d028fe4", "links": {"self": {"href": "https://publications.scilifelab.se/publication/77da5ef1c8c94bc48cce4fe25d028fe4.json"}, "display": {"href": "https://publications.scilifelab.se/publication/77da5ef1c8c94bc48cce4fe25d028fe4"}}, "title": "Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation.", "authors": [{"family": "Gurav", "given": "Deepanjali", "initials": "D"}, {"family": "Varghese", "given": "Oommen P", "initials": "OP"}, {"family": "Hamad", "given": "Osama A", "initials": "OA"}, {"family": "Nilsson", "given": "Bo", "initials": "B"}, {"family": "Hilborn", "given": "J\u00f6ns", "initials": "J"}, {"family": "Oommen", "given": "Oommen P", "initials": "OP"}], "type": "journal article", "published": "2016-01-18", "journal": {"volume": "52", "issn": "1364-548X", "issue": "5", "pages": "966-969", "title": "Chem. Commun. (Camb.)", "issn-l": "1359-7345"}, "abstract": "We have developed the first chondroitin sulfate polymer coated gold nanoparticles that can simultaneously overcome mulidrug resistance in cancer cells and suppress thromboinflammation triggered by the chemotherapeutic drug.", "doi": "10.1039/c5cc09215a", "pmid": "26587574", "labels": {"Karolinska High Throughput Center (KHTC)": "Service"}, "xrefs": [], "notes": [], "created": "2017-05-03T12:59:36.116Z", "modified": "2017-06-12T11:37:46.784Z"}, {"entity": "publication", "iuid": "986458fc9e3e45b98a1a5237922a54b0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/986458fc9e3e45b98a1a5237922a54b0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/986458fc9e3e45b98a1a5237922a54b0"}}, "title": "Exploring water as building bricks in enzyme engineering.", "authors": [{"family": "Hendil-Forssell", "given": "Peter", "initials": "P"}, {"family": "Martinelle", "given": "Mats", "initials": "M"}, {"family": "Syr\u00e9n", "given": "Per-Olof", "initials": "PO"}], "type": "journal article", "published": "2015-12-18", "journal": {"volume": "51", "issn": "1364-548X", "issue": "97", "pages": "17221-17224", "title": "Chem. Commun. (Camb.)", "issn-l": "1359-7345"}, "abstract": "A novel enzyme engineering strategy for accelerated catalysis based on redesigning a water network through protein backbone deshielding is presented. Fundamental insight into the energetic consequences associated with the design is discussed in the light of experimental results and computer simulations. Using water as biobricks provides unique opportunities when transition state stabilisation is not easily attained by traditional enzyme engineering.", "doi": "10.1039/c5cc07162c", "pmid": "26426706", "labels": {"Protein Science Facility (PSF)": null}, "xrefs": [], "notes": [], "created": "2017-05-02T12:57:16.001Z", "modified": "2017-09-06T11:42:09.204Z"}], "created": "2017-05-09T09:12:41.393Z", "modified": "2020-11-27T13:14:02.005Z"}