{"entity": "journal", "iuid": "c44de0f8b08848ce88e9dd801fd3f183", "timestamp": "2026-05-19T07:33:56.824Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Cerebrovasc%20Dis.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Cerebrovasc%20Dis"}}, "title": "Cerebrovasc Dis", "issn": "1421-9786", "issn-l": "1015-9770", "publications_count": 1, "publications": [{"entity": "publication", "iuid": "e2bfec53e7134d05b786d48990624e79", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e2bfec53e7134d05b786d48990624e79.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e2bfec53e7134d05b786d48990624e79"}}, "title": "High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy.", "authors": [{"family": "Edsfeldt", "given": "Andreas", "initials": "A"}, {"family": "Bengtsson", "given": "Eva", "initials": "E"}, {"family": "Asciutto", "given": "Giuseppe", "initials": "G"}, {"family": "Dun\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Bj\u00f6rkbacka", "given": "Harry", "initials": "H"}, {"family": "Fredrikson", "given": "Gunilla Nordin", "initials": "GN"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}], "type": "journal article", "published": "2016-01-27", "journal": {"title": "Cerebrovasc Dis", "issn": "1421-9786", "issn-l": "1015-9770", "volume": "41", "issue": "3-4", "pages": "199-203"}, "abstract": "Galectin-3 (Gal-3) has been suggested to have both pro- and anti-atherogenic properties. High plasma Gal-3 levels are associated with increased risk for cardiovascular (CV) death. However, it has so far not been investigated if plasma Gal-3 levels can predict the risk for future stroke in patients suffering from carotid atherosclerosis. The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA).\n\nPlasma samples were obtained from 558 CEA patients and Gal-3 levels were analyzed by the proximity extension assay technique. The Swedish national in-patient health register was used to identify postoperative cerebrovascular events during the follow-up period (42.6 \u00b1 26.2 months).\n\nPlasma Gal-3 was increased in patients treated for a symptomatic carotid stenosis (p = 0.013). Patients with Gal-3 levels above the median value had an increased incidence of stroke as shown by Kaplan-Meier curves of event-free survival (p = 0.007). Gal-3 was a predictor of postoperative stroke among women (hazard ratio 15.1, 95% CI 1.3-172.2; p = 0.028) even after correction for traditional CV risk factors.\n\nThis study is the first to show that increased plasma levels of Gal-3 can help in predicting the occurrence of postoperative strokes among female subjects who undergo CEA, independently of traditional risk factors for cerebrovascular disease. This finding suggests that Gal-3 could be used as a marker to identify patients in need of intensified postoperative medical care.", "doi": "10.1159/000443022", "pmid": "26812165", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "000443022"}], "notes": [], "created": "2020-01-23T15:07:34.373Z", "modified": "2023-04-14T13:56:22.602Z"}], "created": "2020-01-23T15:07:34.388Z", "modified": "2020-11-27T13:14:02.368Z"}