{"entity": "journal", "iuid": "9c667d8fc4374c378c8e2ec93ad2d152", "timestamp": "2026-08-15T22:36:51.892Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Cereb.%20Cortex.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Cereb.%20Cortex"}}, "title": "Cereb. Cortex", "issn": "1460-2199", "issn-l": "1047-3211", "publications_count": 3, "publications": [{"entity": "publication", "iuid": "b79b811e9f0642fd9f549d71ee492460", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b79b811e9f0642fd9f549d71ee492460.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b79b811e9f0642fd9f549d71ee492460"}}, "title": "Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells.", "authors": [{"family": "Wilhelmsson", "given": "Ulrika", "initials": "U"}, {"family": "Lebkuechner", "given": "Isabell", "initials": "I"}, {"family": "Leke", "given": "Renata", "initials": "R"}, {"family": "Marasek", "given": "Pavel", "initials": "P"}, {"family": "Yang", "given": "Xiaoguang", "initials": "X"}, {"family": "Antfolk", "given": "Daniel", "initials": "D"}, {"family": "Chen", "given": "Meng", "initials": "M"}, {"family": "Mohseni", "given": "Paria", "initials": "P"}, {"family": "Lasi\u010d", "given": "Eva", "initials": "E"}, {"family": "Bobnar", "given": "Sa\u0161a Trkov", "initials": "ST"}, {"family": "Stenovec", "given": "Matja\u017e", "initials": "M"}, {"family": "Zorec", "given": "Robert", "initials": "R"}, {"family": "Nagy", "given": "Andras", "initials": "A"}, {"family": "Sahlgren", "given": "Cecilia", "initials": "C"}, {"family": "Pekna", "given": "Marcela", "initials": "M"}, {"family": "Pekny", "given": "Milos", "initials": "M"}], "type": "journal article", "published": "2019-09-13", "journal": {"title": "Cereb. Cortex", "issn": "1460-2199", "volume": "29", "issue": "10", "pages": "4050-4066", "issn-l": "1047-3211"}, "abstract": "The intermediate filament (nanofilament) protein nestin is a marker of neural stem cells, but its role in neurogenesis, including adult neurogenesis, remains unclear. Here, we investigated the role of nestin in neurogenesis in adult nestin-deficient (Nes-/-) mice. We found that the proliferation of Nes-/- neural stem cells was not altered, but neurogenesis in the hippocampal dentate gyrus of Nes-/- mice was increased. Surprisingly, the proneurogenic effect of nestin deficiency was mediated by its function in the astrocyte niche. Through its role in Notch signaling from astrocytes to neural stem cells, nestin negatively regulates neuronal differentiation and survival; however, its expression in neural stem cells is not required for normal neurogenesis. In behavioral studies, nestin deficiency in mice did not affect associative learning but was associated with impaired long-term memory.", "doi": "10.1093/cercor/bhy284", "pmid": "30605503", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "5263979"}], "notes": [], "created": "2020-01-23T16:15:12.816Z", "modified": "2021-06-18T14:08:06.008Z"}, {"entity": "publication", "iuid": "8210d101bd0a4b3f8307061e9443d54a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8210d101bd0a4b3f8307061e9443d54a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8210d101bd0a4b3f8307061e9443d54a"}}, "title": "Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.", "authors": [{"family": "Bazov", "given": "Igor", "initials": "I"}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D"}, {"family": "Kononenko", "given": "Olga", "initials": "O"}, {"family": "Watanabe", "given": "Hiroyuki", "initials": "H"}, {"family": "Taqi", "given": "Mumtaz Malik", "initials": "MM"}, {"family": "St\u00e5lhandske", "given": "Lada", "initials": "L"}, {"family": "Verbeek", "given": "Dineke S", "initials": "DS"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Rajkowska", "given": "Grazyna", "initials": "G"}, {"family": "Sheedy", "given": "Donna", "initials": "D"}, {"family": "Kril", "given": "Jillian", "initials": "J"}, {"family": "Sun", "given": "Xueguang", "initials": "X"}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC", "orcid": "0000-0002-9681-9146", "researcher": {"href": "https://publications.scilifelab.se/researcher/f7012e35025543379380cb90efd71243.json"}}, {"family": "Yakovleva", "given": "Tatiana", "initials": "T"}, {"family": "Bakalkin", "given": "Georgy", "initials": "G"}], "type": "journal article", "published": "2018-09-01", "journal": {"volume": "28", "issn": "1460-2199", "issue": "9", "pages": "3129-3142", "title": "Cereb. Cortex", "issn-l": "1047-3211"}, "abstract": "Molecular mechanisms that define patterns of neuropeptide expression are essential for the formation and rewiring of neural circuits. The prodynorphin gene (PDYN) gives rise to dynorphin opioid peptides mediating depression and substance dependence. We here demonstrated that PDYN is expressed in neurons in human dorsolateral prefrontal cortex (dlPFC), and identified neuronal differentially methylated region in PDYN locus framed by CCCTC-binding factor binding sites. A short, nucleosome size human-specific promoter CpG island (CGI), a core of this region may serve as a regulatory module, which is hypomethylated in neurons, enriched in 5-hydroxymethylcytosine, and targeted by USF2, a methylation-sensitive E-box transcription factor (TF). USF2 activates PDYN transcription in model systems, and binds to nonmethylated CGI in dlPFC. USF2 and PDYN expression is correlated, and USF2 and PDYN proteins are co-localized in dlPFC. Segregation of activatory TF and repressive CGI methylation may ensure contrasting PDYN expression in neurons and glia in human brain.", "doi": "10.1093/cercor/bhx181", "pmid": "28968778", "labels": {"Fluorescence Tissue Profiling": "Collaborative", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "4049562"}], "notes": [], "created": "2017-10-30T14:56:20.881Z", "modified": "2024-01-16T13:48:45.553Z"}, {"entity": "publication", "iuid": "58ac3a28707245c785c96dd26ae5d18c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/58ac3a28707245c785c96dd26ae5d18c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/58ac3a28707245c785c96dd26ae5d18c"}}, "title": "Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain.", "authors": [{"family": "Wilhelmsson", "given": "Ulrika", "initials": "U"}, {"family": "Andersson", "given": "Daniel", "initials": "D"}, {"family": "de Pablo", "given": "Yolanda", "initials": "Y"}, {"family": "Pekny", "given": "Roy", "initials": "R"}, {"family": "St\u00e5hlberg", "given": "Anders", "initials": "A"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Mitsios", "given": "Nicholas", "initials": "N"}, {"family": "Hortob\u00e1gyi", "given": "Tibor", "initials": "T"}, {"family": "Pekny", "given": "Milos", "initials": "M"}, {"family": "Pekna", "given": "Marcela", "initials": "M"}], "type": "journal article", "published": "2017-06-01", "journal": {"volume": "27", "issn": "1460-2199", "issue": "6", "pages": "3360-3377", "title": "Cereb. Cortex", "issn-l": "1047-3211"}, "abstract": "Microglia and astrocytes have been considered until now as cells with very distinct identities. Here, we assessed the heterogeneity within microglia/monocyte cell population in mouse hippocampus and determined their response to injury, by using single-cell gene expression profiling of cells isolated from uninjured and deafferented hippocampus. We found that in individual cells, microglial markers Cx3cr1, Aif1, Itgam, and Cd68 were co-expressed. Interestingly, injury led to the co-expression of the astrocyte marker Gfap in a subpopulation of Cx3cr1-expressing cells from both the injured and contralesional hippocampus. Cells co-expressing astrocyte and microglia markers were also detected in the in vitro LPS activation/injury model and in sections from human brain affected by stroke, Alzheimer's disease, and Lewy body dementia. Our findings indicate that injury and chronic neurodegeneration lead to the appearance of cells that share molecular characteristics of both microglia and astrocytes, 2 cell types with distinct embryologic origin and function.", "doi": "10.1093/cercor/bhx069", "pmid": "28398520", "labels": {"Fluorescence Tissue Profiling": "Collaborative", "Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "3111278"}], "notes": [], "created": "2017-10-30T14:57:53.920Z", "modified": "2021-05-24T15:37:29.389Z"}], "created": "2017-10-30T14:56:20.914Z", "modified": "2020-11-27T13:14:02.936Z"}