{"entity": "journal", "iuid": "7d357e8fc2d74f92930b4cd086ab921e", "timestamp": "2026-03-05T08:50:02.707Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/BMC%20Pulm%20Med.json"}, "display": {"href": "https://publications.scilifelab.se/journal/BMC%20Pulm%20Med"}}, "title": "BMC Pulm Med", "issn": "1471-2466", "issn-l": "1471-2466", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "3ef89dc74e2648e6917a87d7e601859e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3ef89dc74e2648e6917a87d7e601859e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3ef89dc74e2648e6917a87d7e601859e"}}, "title": "IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation.", "authors": [{"family": "J\u00f3nsd\u00f3ttir", "given": "Brynja", "initials": "B"}, {"family": "Jaworowski", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "San Miguel", "given": "Carmen", "initials": "C"}, {"family": "Melander", "given": "Olle", "initials": "O"}], "type": "journal article", "published": "2017-02-08", "journal": {"title": "BMC Pulm Med", "issn": "1471-2466", "issn-l": "1471-2466", "volume": "17", "issue": "1", "pages": "35"}, "abstract": "Patients with Acute Hypercapnic Respiratory Failure (AHRF) who are unresponsive to appropriate medical treatment, are often treated with Noninvasive Positive Pressure Ventilation (NPPV). Clinical predictors of the outcome of this treatment are scarce. Therefore, we evaluated the role of the biomarkers IL-8 and GDF-15 in predicting 28-day mortality in patients with AHRF who receive treatment with NPPV.\n\nThe study population were 46 patients treated with NPPV for AHRF. Clinical and background data was registered and blood samples taken for analysis of inflammatory biomarkers. IL-8 and GDF-15 were selected for analysis, and related to risk of 28-day mortality (primary endpoint) using Cox proportional hazard models adjusted for gender, age and various clinical parameters.\n\nOf the 46 patients, there were 3 subgroup in regards to primary diagnosis: Acute Exacerbation of COPD (AECOPD, n = 34), Acute Heart Failure (AHF, n = 8) and Acute Exacerbation in Obesity Hypoventilation Syndrome (AEOHS, n = 4). There was significant difference in the basic characteristic of the subgroups, but not in the clinical parameters that were used in treatment decisions. 13 patients died within 28 days of admission (28%). The Hazard Ratio for 28-days mortality per 1-SD increment of IL-8 was 3.88 (95% CI 1.86-8.06, p < 0.001). When IL-8 values were divided into tertiles, the highest tertile had a significant association with 28 days mortality, HR 10.02 (95% CI 1.24-80.77, p for trend 0.03), compared with the lowest tertile. This correlation was maintained when the largest subgroup with AECOPD was analyzed. GDF-15 was correlated in the same way, but when put into the same model as IL-8, the significance disappeared.\n\nIL-8 is a target to explore further as a predictor of 28 days mortality, in patients with AHRF treated with NPPV.", "doi": "10.1186/s12890-017-0377-7", "pmid": "28178959", "labels": {"Clinical Biomarkers": "Service", "Affinity Proteomics Stockholm": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "10.1186/s12890-017-0377-7"}, {"db": "pmc", "key": "PMC5299680"}], "notes": [], "created": "2020-01-23T15:13:41.234Z", "modified": "2023-04-14T13:56:17.622Z"}, {"entity": "publication", "iuid": "9d0dbd0a7c174475b6db9172fedd74cc", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9d0dbd0a7c174475b6db9172fedd74cc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9d0dbd0a7c174475b6db9172fedd74cc"}}, "title": "Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease.", "authors": [{"family": "Matsson", "given": "Hans", "initials": "H"}, {"family": "S\u00f6derh\u00e4ll", "given": "Cilla", "initials": "C"}, {"family": "Einarsdottir", "given": "Elisabet", "initials": "E"}, {"family": "Lamontagne", "given": "Maxime", "initials": "M"}, {"family": "Gudmundsson", "given": "Sanna", "initials": "S"}, {"family": "Backman", "given": "Helena", "initials": "H"}, {"family": "Lindberg", "given": "Anne", "initials": "A"}, {"family": "R\u00f6nmark", "given": "Eva", "initials": "E"}, {"family": "Kere", "given": "Juha", "initials": "J"}, {"family": "Sin", "given": "Don", "initials": "D"}, {"family": "Postma", "given": "Dirkje S", "initials": "DS"}, {"family": "Boss\u00e9", "given": "Yohan", "initials": "Y"}, {"family": "Lundb\u00e4ck", "given": "Bo", "initials": "B"}, {"family": "Klar", "given": "Joakim", "initials": "J"}], "type": "journal article", "published": "2016-11-11", "journal": {"volume": "16", "issn": "1471-2466", "issue": "1", "pages": "146", "title": "BMC Pulm Med", "issn-l": "1471-2466"}, "abstract": "Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candidate genes for COPD.\n\nExons in 22 genes implicated in lung development as well as 61 genes and 10 genomic regions previously associated with COPD were sequenced using individual DNA samples from 68 cases with moderate or severe COPD and 66 controls matched for age, gender and smoking. Cases and controls were selected from the Obstructive Lung Disease in Northern Sweden (OLIN) studies.\n\nIn total, 37 genetic variants showed association with COPD (p\u2009<\u20090.05, uncorrected). Several variants previously discovered to be associated with COPD from genetic genome-wide analysis studies were replicated using our sample. Two high-risk variants were followed-up for functional characterization in a large eQTL mapping study of 1,111 human lung specimens. The C allele of a synonymous variant, rs8040868, predicting a p.(S45=) in the gene for cholinergic receptor nicotinic alpha 3 (CHRNA3) was associated with COPD (p\u2009=\u20098.8 x 10(-3)). This association remained (p\u2009=\u20090.003 and OR\u2009=\u20091.4, 95\u00a0% CI 1.1-1.7) when analysing all available cases and controls in OLIN (n\u2009=\u20091,534). The rs8040868 variant is in linkage disequilibrium with rs16969968 previously associated with COPD and altered expression of the CHRNA5 gene. A follow-up analysis for detection of expression quantitative trait loci revealed that rs8040868-C was found to be significantly associated with a decreased expression of the nearby gene cholinergic receptor, nicotinic, alpha 5 (CHRNA5) in lung tissue.\n\nOur data replicate previous result suggesting CHRNA5 as a candidate gene for COPD and rs8040868 as a risk variant for the development of COPD in the Swedish population.", "doi": "10.1186/s12890-016-0309-y", "pmid": "27835950", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "10.1186/s12890-016-0309-y"}, {"db": "pmc", "key": "PMC5106844"}], "notes": [], "created": "2017-05-03T13:00:21.938Z", "modified": "2024-01-16T13:48:48.996Z"}], "created": "2017-05-09T09:12:14.185Z", "modified": "2020-11-27T13:14:03.723Z"}