{"entity": "journal", "iuid": "ddae7f187b8c4f5db0b55271cb37e1d8", "timestamp": "2026-08-09T13:50:04.657Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Arch.%20Dermatol.%20Res..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Arch.%20Dermatol.%20Res."}}, "title": "Arch. Dermatol. Res.", "issn": "1432-069X", "issn-l": "0340-3696", "publications_count": 2, "publications": [{"entity": "publication", "iuid": "8cb386a56a944702a949588e0e204cfa", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8cb386a56a944702a949588e0e204cfa.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8cb386a56a944702a949588e0e204cfa"}}, "title": "SATB2 is expressed in Merkel cell carcinoma.", "authors": [{"family": "Fukuhara", "given": "Mari", "initials": "M"}, {"family": "Agnarsd\u00f3ttir", "given": "Margr\u00e9t", "initials": "M"}, {"family": "Edqvist", "given": "Per-Henrik", "initials": "PH"}, {"family": "Coter", "given": "Anna", "initials": "A"}, {"family": "Ponten", "given": "Fredrik", "initials": "F"}], "type": "journal article", "published": "2016-08-00", "journal": {"volume": "308", "issn": "1432-069X", "issue": "6", "pages": "449-454", "title": "Arch. Dermatol. Res.", "issn-l": "0340-3696"}, "abstract": "Merkel cell carcinoma (MCC) is a rare aggressive skin cancer with neuroendocrine differentiation. With immunohistochemistry, the tumor cells stain for both neuroendocrine (i.e., synaptophysin and chromogranin A) and epithelial markers. The epithelial marker cytokeratin 20 (CK20) stains positive with immunohistochemistry in a vast majority of MCCs. The expression of the special AT-rich sequence-binding protein (SATB2) was analyzed in MCC (n\u00a0=\u00a020) together with other forms of skin cancer and neuroendocrine tumors (n\u00a0=\u00a051) using immunohistochemistry. The results were compared to the expression of CK20, synaptophysin, and chromogranin A. The majority of the MCCs stained positive for synaptophysin and chromogranin A (95 vs 80\u00a0% respectively), and 75\u00a0% of the MCCs showed cytoplasmic positivity for CK20 and nuclear positivity for SATB2, with two discordant cases lacking expression of one of these markers. We conclude that immunohistochemistry for SATB2 can be used as an additional marker with similar sensitivity and specificity as CK20 for the diagnosis of Merkel cell carcinoma, suggesting a clinical utility in difficult cases where MCC is suspected.", "doi": "10.1007/s00403-016-1655-6", "pmid": "27262585", "labels": {"Tissue Profiling": "Technology development"}, "xrefs": [{"db": "pii", "key": "10.1007/s00403-016-1655-6"}], "notes": [], "created": "2017-05-03T12:59:16.398Z", "modified": "2017-11-05T12:52:05.212Z"}, {"entity": "publication", "iuid": "a89a4f4347a64c159d56300081f3b1d0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/a89a4f4347a64c159d56300081f3b1d0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/a89a4f4347a64c159d56300081f3b1d0"}}, "title": "Ichthyin/NIPAL4 localizes to keratins and desmosomes in epidermis and Ichthyin mutations affect epidermal lipid metabolism.", "authors": [{"family": "Dahlqvist", "given": "Johanna", "initials": "J"}, {"family": "Westermark", "given": "Gunilla T", "initials": "GT"}, {"family": "Vahlquist", "given": "Anders", "initials": "A"}, {"family": "Dahl", "given": "Niklas", "initials": "N"}], "type": "journal article", "published": "2012-07-00", "journal": {"volume": "304", "issn": "1432-069X", "issue": "5", "pages": "377-386", "title": "Arch. Dermatol. Res.", "issn-l": "0340-3696"}, "abstract": "Autosomal recessive congenital ichthyosis (ARCI) is a group of disorders characterized by abnormal desquamation of the skin and a disrupted epidermal water barrier. Ichthyin/NIPAL4 gene mutations have been identified in a subgroup of ARCI patients, but the role of ichthyin in epidermis remains elusive. In order to obtain new insights concerning the characteristics of ichthyin and the ARCI pathogenesis, we studied the expression and localization of ichthyin and related epidermal components in cultured keratinocytes and skin sections from patients with Ichthyin mutations and healthy controls. We observed an up-regulation of Ichthyin mRNA levels after in vitro differentiation of keratinocytes from both a patient with Ichthyin mutations and controls. Confocal and electron microscopy analyses of immunolabeled skin sections revealed that ichthyin localizes to desmosomes and keratins in both patients with mutant Ichthyin and controls, with an increased immunolabeling in patients. Nile red lipid analysis of skin sections exposed intra-cellular lipid accumulations in cells of the granular and cornified layers in patients but not in controls, consistent with the pathognomonic lipid membrane structures previously identified in epidermis from patients. Our combined findings indicate that ichthyin is associated with keratins and desmosomes in epidermis and is involved in lipid metabolism, possibly through processing of lamellar bodies. These results provide new clues to the understanding of the epidermal water barrier and the pathogenesis in ARCI.", "doi": "10.1007/s00403-012-1207-7", "pmid": "22258272", "labels": {"National Genomics Infrastructure": null, "NGI Stockholm (Genomics Applications)": null, "NGI Stockholm (Genomics Production)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T14:57:29.505Z", "modified": "2020-01-21T13:56:04.394Z"}], "created": "2017-05-09T09:12:28.005Z", "modified": "2020-11-27T13:14:02.486Z"}