{"entity": "journal", "iuid": "df5822232c604dcdaeb7e3d0a59d0555", "timestamp": "2026-07-14T03:47:46.217Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Antibiotics%20%28Basel%29.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Antibiotics%20%28Basel%29"}}, "title": "Antibiotics (Basel)", "issn": "2079-6382", "issn-l": null, "publications_count": 3, "publications": [{"entity": "publication", "iuid": "2c25ac8902974f2bad8f06180c49be2f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2c25ac8902974f2bad8f06180c49be2f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2c25ac8902974f2bad8f06180c49be2f"}}, "title": "Treatment of Periprosthetic Joint Infection with Intravenous Vancomycin: Do We Hit the Target?", "authors": [{"family": "Haglund", "given": "Rasmus", "initials": "R"}, {"family": "Tornberg", "given": "Ulrika", "initials": "U"}, {"family": "Claesson", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Freyhult", "given": "Eva", "initials": "E", "orcid": "0000-0003-0226-1047", "researcher": {"href": "https://publications.scilifelab.se/researcher/be110f11a53d4dcfa3bfd1657167895e.json"}}, {"family": "Hailer", "given": "Nils P", "initials": "NP", "orcid": "0000-0002-3233-2638", "researcher": {"href": "https://publications.scilifelab.se/researcher/4c8bb8c013184ef7b482ffe6f8f1380b.json"}}], "type": "journal article", "published": "2024-12-18", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "13", "issue": "12", "issn-l": null}, "abstract": "Background/objectives: Vancomycin is commonly used in the treatment of periprosthetic joint infection (PJI), and trough concentrations are measured to ascertain that they are within the therapeutic range. It has not been investigated what proportion of vancomycin concentrations during treatment of PJI patients is accurately within this range, how many dose adjustments are commonly needed, and which patient factors predispose towards aberrations from the desired range. Method: In this single-center cohort study, we investigated vancomycin trough concentrations in 108 patients with surgically treated PJI who received IV administered vancomycin treatment post-operatively. Patients were identified in our local arthroplasty register, and data beyond what was available in the register were collected from electronic medical charts. Results: Of the final study cohort, 41% were women, and the median age was 71 (IQR 63-79) years. Most patients had PJI of the hip (73%), the majority (54%) underwent a debridement, antibiotics and implant retention (DAIR) procedure prior to vancomycin treatment, and 39% received vancomycin-loaded bone cement during the preceding revision procedure. Of 791 vancomycin trough measurements, only 58.2% were within the target range of 15-20 mg/L, 18.5% were below, and 23.4% were above. A total of 71% of all patients required at least one dose adjustment, and the median length of vancomycin treatment was 8 days. We observed positive correlations of vancomycin trough concentrations with both age (Spearman's rho = 0.35, p < 0.001) and pre-treatment creatinine concentrations (Spearman's rho = 0.34, p < 0.001), but no statistically significant difference between patients who had received vancomycin-loaded bone cement and those who had not. Conclusions: In our PJI patients, a high proportion of vancomycin trough concentrations were outside the therapeutic range, despite adherence to local and national guidelines. We can also confirm that caution needs to be exerted in patients of advanced age and those with compromised kidney function. Alternative broad-spectrum antibiotics that do not require as extensive therapeutic drug monitoring should be further explored.", "doi": "10.3390/antibiotics13121226", "pmid": "39766617", "labels": {"Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics Support and Infrastructure": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC11727632"}, {"db": "pii", "key": "antibiotics13121226"}], "notes": [], "created": "2025-02-17T09:20:45.877Z", "modified": "2025-02-17T09:20:46.439Z"}, {"entity": "publication", "iuid": "aeb82ce0499b472fa5e9418a3add8981", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aeb82ce0499b472fa5e9418a3add8981.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aeb82ce0499b472fa5e9418a3add8981"}}, "title": "Genomic Analyses of Methicillin-Resistant Staphylococcus pseudintermedius from Companion Animals Reveal Changing Clonal Populations, Multidrug Resistance, and Virulence.", "authors": [{"family": "Myren\u00e5s", "given": "Mattias", "initials": "M", "orcid": "0000-0002-0537-3266", "researcher": {"href": "https://publications.scilifelab.se/researcher/6edeef05dacd4bdbbf3d18e4a884a2d5.json"}}, {"family": "Pedersen", "given": "Karl", "initials": "K", "orcid": "0000-0001-5013-7409", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb350394fb3747b2b3992c2289fac376.json"}}, {"family": "Windahl", "given": "Ulrika", "initials": "U", "orcid": "0000-0001-9311-6982", "researcher": {"href": "https://publications.scilifelab.se/researcher/491cae6265604308bbb979f69bb033b6.json"}}], "type": "journal article", "published": "2024-10-12", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "volume": "13", "issue": "10", "pages": "962", "issn-l": null}, "abstract": "Staphylococcus pseudintermedius is part of the normal microbiota in dogs. Since 2006, an increase in multidrug-resistant clones of methicillin-resistant S. pseudintermedius has been reported, as well as zoonotic transmission. Longitudinal investigations into clonal population structures, antibiotic resistance patterns, and the presence of resistance and virulence genes are important tools for gaining knowledge of the mechanisms behind the emergence of such clones.\n\nWe investigated 87% of all non-repetitive MRSP isolates from dogs and cats in Sweden over a ten-year period (n = 356). All isolates were subjected to staphylococcal chromosomal cassette mec identification, whole-genome sequencing, multi-locus sequence typing, and analyses of genomic relatedness, as well as investigation of phenotypical resistance patterns and the presence of antibiotic resistance genes and virulence genes.\n\nA considerable increase over time in the number of clonal lineages present was observed, indicating genomic diversification, and four clones became dominant: ST71, ST258, ST265, and ST551. In total, 96% of the isolates were multidrug-resistant. Statistically significant differences in resistance to several antibiotic classes between the four dominant clones were present. All isolates carried several virulence genes encoding factors associated with attachment, colonization, toxin synthesis, quorum sensing, antibiotic resistance, and immune evasion.", "doi": "10.3390/antibiotics13100962", "pmid": "39452228", "labels": {"Clinical Genomics Stockholm": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11505346"}, {"db": "pii", "key": "antibiotics13100962"}], "notes": [], "created": "2024-11-20T20:46:11.716Z", "modified": "2025-12-04T19:37:59.713Z"}, {"entity": "publication", "iuid": "f8b2aad10ba84e868680d663819912c7", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f8b2aad10ba84e868680d663819912c7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f8b2aad10ba84e868680d663819912c7"}}, "title": "Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel \u03b2-Lactam-Metallo-\u03b2-Lactamase Inhibitors.", "authors": [{"family": "Reddy", "given": "Nakita", "initials": "N"}, {"family": "Girdhari", "given": "Letisha", "initials": "L", "orcid": "0000-0001-5841-2735", "researcher": {"href": "https://publications.scilifelab.se/researcher/249183863e6842a59f3b2bba5c3d0670.json"}}, {"family": "Shungube", "given": "Mbongeni", "initials": "M"}, {"family": "Gouws", "given": "Arnoldus C", "initials": "AC", "orcid": "0000-0002-9848-719X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ba06527dc4bd4d54b7ccf4db223f0691.json"}}, {"family": "Peters", "given": "Byron K", "initials": "BK"}, {"family": "Rajbongshi", "given": "Kamal K", "initials": "KK", "orcid": "0000-0003-0128-663X", "researcher": {"href": "https://publications.scilifelab.se/researcher/b42da27a8b384a6684037107d0a158ca.json"}}, {"family": "Baijnath", "given": "Sooraj", "initials": "S", "orcid": "0000-0001-7860-1779", "researcher": {"href": "https://publications.scilifelab.se/researcher/a918cd14121f40bf88ad33082921e5c2.json"}}, {"family": "Mdanda", "given": "Sipho", "initials": "S", "orcid": "0000-0003-0146-0538", "researcher": {"href": "https://publications.scilifelab.se/researcher/564e56b376b04f2d996a425c16013a77.json"}}, {"family": "Ntombela", "given": "Thandokuhle", "initials": "T"}, {"family": "Arumugam", "given": "Thilona", "initials": "T"}, {"family": "Bester", "given": "Linda A", "initials": "LA", "orcid": "0000-0001-5726-681X", "researcher": {"href": "https://publications.scilifelab.se/researcher/15b4bc949845434a9b612be0e28764a5.json"}}, {"family": "Singh", "given": "Sanil D", "initials": "SD"}, {"family": "Chuturgoon", "given": "Anil", "initials": "A", "orcid": "0000-0003-4649-4133", "researcher": {"href": "https://publications.scilifelab.se/researcher/f96bfd695ee44484ad9b87f9ef4e76a0.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI", "orcid": "0000-0002-9453-6812", "researcher": {"href": "https://publications.scilifelab.se/researcher/ae064b90b750457e80e974947f2dfc7a.json"}}, {"family": "Maguire", "given": "Glenn E M", "initials": "GEM"}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications.scilifelab.se/researcher/578365860e2b45b1aa8004d88e2f311c.json"}}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/88d16e433761470da735d3191d23a68a.json"}}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications.scilifelab.se/researcher/dfe71fc16c2240af9919d68b69d7d652.json"}}], "type": "journal article", "published": "2023-03-23", "journal": {"title": "Antibiotics (Basel)", "issn": "2079-6382", "issn-l": null, "volume": "12", "issue": "4", "pages": null}, "abstract": "Virulent Enterobacterale strains expressing serine and metallo-\u03b2-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop \u03b2-lactamase inhibitors to counter this resistance. Currently, serine \u03b2-lactamase inhibitors (SBLIs) are in therapeutic use. However, an urgent global need for clinical metallo-\u03b2-lactamase inhibitors (MBLIs) has become dire. To address this problem, this study evaluated BP2, a novel beta-lactam-derived \u03b2-lactamase inhibitor, co-administered with meropenem. According to the antimicrobial susceptibility results, BP2 potentiates the synergistic activity of meropenem to a minimum inhibitory concentration (MIC) of \u22641 mg/L. In addition, BP2 is bactericidal over 24 h and safe to administer at the selected concentrations. Enzyme inhibition kinetics showed that BP2 had an apparent inhibitory constant (Kiapp) of 35.3 \u00b5M and 30.9 \u00b5M against New Delhi Metallo-\u03b2-lactamase (NDM-1) and Verona Integron-encoded Metallo-\u03b2-lactamase (VIM-2), respectively. BP2 did not interact with glyoxylase II enzyme up to 500 \u00b5M, indicating specific (MBL) binding. In a murine infection model, BP2 co-administered with meropenem was efficacious, observed by the >3 log10 reduction in K. pneumoniae NDM cfu/thigh. Given the promising pre-clinical results, BP2 is a suitable candidate for further research and development as an (MBLI).", "doi": "10.3390/antibiotics12040633", "pmid": "37106995", "labels": {"Drug Discovery and Development": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10135050"}, {"db": "pii", "key": "antibiotics12040633"}], "notes": [], "created": "2024-01-16T15:19:03.368Z", "modified": "2025-10-17T13:05:07.644Z"}], "created": "2024-01-16T15:19:04.309Z", "modified": "2024-01-16T15:19:04.310Z"}