{"entity": "journal", "iuid": "01eeda367ab043fc84e2ffdd86570987", "timestamp": "2026-10-14T18:59:38.183Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Am.%20J.%20Hematol..json"}, "display": {"href": "https://publications.scilifelab.se/journal/Am.%20J.%20Hematol."}}, "title": "Am. J. Hematol.", "issn": "1096-8652", "issn-l": "0361-8609", "publications_count": 7, "publications": [{"entity": "publication", "iuid": "239c56876b514de5ac01c6d5c716ba98", "links": {"self": {"href": "https://publications.scilifelab.se/publication/239c56876b514de5ac01c6d5c716ba98.json"}, "display": {"href": "https://publications.scilifelab.se/publication/239c56876b514de5ac01c6d5c716ba98"}}, "title": "Dabigatran Concentrations in an Actively Breastfeeding Mother-Infant Dyad: Extending the Evidence for Oral Thromboprophylaxis Postpartum.", "authors": [{"family": "Green", "given": "Rasmus W", "initials": "RW", "orcid": "0000-0001-6575-2447", "researcher": {"href": "https://publications.scilifelab.se/researcher/35553a3c60d842a4a31d650a5b793e17.json"}}, {"family": "Saleh", "given": "Aljona", "initials": "A", "orcid": "0009-0002-2121-043X", "researcher": {"href": "https://publications.scilifelab.se/researcher/c469c0a07dc746c2a16b122c2269480c.json"}}, {"family": "Baranczewski", "given": "Pawel", "initials": "P", "orcid": "0000-0001-5772-6791", "researcher": {"href": "https://publications.scilifelab.se/researcher/47f7af2466c14275a42aad4a431b2dcb.json"}}], "type": "letter", "published": "2026-04-16", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "issn-l": "0361-8609"}, "abstract": null, "doi": "10.1002/ajh.70318", "pmid": "41992716", "labels": {"Drug Discovery and Development": "Collaborative"}, "xrefs": [], "notes": [], "created": "2026-05-14T20:17:57.798Z", "modified": "2026-05-14T20:17:58.184Z"}, {"entity": "publication", "iuid": "00acb4e8c46548948ab33a099f72a78f", "links": {"self": {"href": "https://publications.scilifelab.se/publication/00acb4e8c46548948ab33a099f72a78f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/00acb4e8c46548948ab33a099f72a78f"}}, "title": "Mutation in the TACI gene and autoimmune neutropenia: A case report.", "authors": [{"family": "Bergman", "given": "Peter", "initials": "P"}, {"family": "Broliden", "given": "Per-Anders", "initials": "PA"}, {"family": "Ratcliffe", "given": "Paul", "initials": "P"}, {"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications.scilifelab.se/researcher/64d9a0bc6b5d4039af5bc308a97eaad6.json"}}, {"family": "Flesch", "given": "Brigitte", "initials": "B", "orcid": "0000-0001-5485-2645", "researcher": {"href": "https://publications.scilifelab.se/researcher/292dc88cdd4c457db175940238e6ddfa.json"}}, {"family": "H\u00f6glund", "given": "Petter", "initials": "P"}, {"family": "Palmblad", "given": "Jan", "initials": "J", "orcid": "0000-0003-4014-2540", "researcher": {"href": "https://publications.scilifelab.se/researcher/899d044878cb466f9c39cc5d89080bed.json"}}], "type": "case reports", "published": "2022-06-01", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "volume": "97", "issue": "6", "pages": "E207-E210", "issn-l": "0361-8609"}, "abstract": null, "doi": "10.1002/ajh.26532", "pmid": "35293001", "labels": {"Clinical Genomics Stockholm": "Service", "Clinical Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2022-11-30T05:59:33.186Z", "modified": "2022-11-30T05:59:33.280Z"}, {"entity": "publication", "iuid": "baf3907fcd9841ca8aa8b14f07ee87fe", "links": {"self": {"href": "https://publications.scilifelab.se/publication/baf3907fcd9841ca8aa8b14f07ee87fe.json"}, "display": {"href": "https://publications.scilifelab.se/publication/baf3907fcd9841ca8aa8b14f07ee87fe"}}, "title": "The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia.", "authors": [{"family": "Mou", "given": "Tian", "initials": "T", "orcid": "0000-0001-7707-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/34923a97e41d4c3690908aa605e8c654.json"}}, {"family": "Pawitan", "given": "Yudi", "initials": "Y"}, {"family": "Stahl", "given": "Matthias", "initials": "M"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M"}, {"family": "Deng", "given": "Wenjiang", "initials": "W"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "\u00d6sterroos", "given": "Albin", "initials": "A"}, {"family": "Siavelis", "given": "Loannis", "initials": "L"}, {"family": "B\u00e4ckvall", "given": "Helena", "initials": "H"}, {"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "Kiviluoto", "given": "Santeri", "initials": "S"}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Orre", "given": "Lukas M", "initials": "LM"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Vu", "given": "Trung Nghia", "initials": "TN"}], "type": "comparative study", "published": "2021-05-01", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "volume": "96", "issue": "5", "pages": "580-588", "issn-l": "0361-8609"}, "abstract": "Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome-wide mRNAs that are specific to each of the molecular subtypes of AML. We analyzed RNA-sequencing data of 955 AML samples from three cohorts, including the BeatAML project, the Cancer Genome Atlas, and a cohort of Swedish patients to provide a comprehensive transcriptome-wide view of subtype-specific mRNA expression. We identified 729 subtype-specific mRNAs, discovered in the BeatAML project and validated in the other two cohorts. Using unique proteomics data, we also validated the presence of subtype-specific mRNAs at the protein level, yielding a rich collection of potential protein-based biomarkers for the AML community. To enable the exploration of subtype-specific mRNA expression by the broader scientific community, we provide an interactive resource to the public.", "doi": "10.1002/ajh.26141", "pmid": "33625756", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-27T21:41:20.524Z", "modified": "2024-01-16T13:48:39.834Z"}, {"entity": "publication", "iuid": "90da40e1f7324fa4a32dc842a59eb5aa", "links": {"self": {"href": "https://publications.scilifelab.se/publication/90da40e1f7324fa4a32dc842a59eb5aa.json"}, "display": {"href": "https://publications.scilifelab.se/publication/90da40e1f7324fa4a32dc842a59eb5aa"}}, "title": "Clonal hematopoiesis in patients with high-grade B-cell lymphoma is associated with inferior outcome.", "authors": [{"family": "Amini", "given": "Rose-Marie", "initials": "RM", "orcid": "0000-0003-0901-5252", "researcher": {"href": "https://publications.scilifelab.se/researcher/c157abcd61fa4900b5ad502b408d6d95.json"}}, {"family": "Ljungstr\u00f6m", "given": "Viktor", "initials": "V"}, {"family": "Abdulla", "given": "Maysaa", "initials": "M", "orcid": "0000-0002-0766-0656", "researcher": {"href": "https://publications.scilifelab.se/researcher/7aa1427f158d44448862d0f1f28723b2.json"}}, {"family": "Cavelier", "given": "Lucia", "initials": "L", "orcid": "0009-0003-8195-370X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f01226edb140436da0c9d166c1f5fe51.json"}}, {"family": "Pandzic", "given": "Tatjana", "initials": "T"}, {"family": "Hollander", "given": "Peter", "initials": "P", "orcid": "0000-0002-0226-5681", "researcher": {"href": "https://publications.scilifelab.se/researcher/b1c6693d3ede463eb78e6da010db601f.json"}}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications.scilifelab.se/researcher/17370bd509dc4b1081af5aed9e5117c7.json"}}], "type": "letter", "published": "2020-07-06", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "volume": "95", "issue": "10", "pages": null, "issn-l": "0361-8609"}, "abstract": null, "doi": "10.1002/ajh.25927", "pmid": "32628289", "labels": {"Clinical Genomics Uppsala": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [], "notes": [], "created": "2020-11-06T13:03:32.457Z", "modified": "2021-11-10T12:49:27.847Z"}, {"entity": "publication", "iuid": "9a523e4820c644a7959df8ad9317e94c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9a523e4820c644a7959df8ad9317e94c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9a523e4820c644a7959df8ad9317e94c"}}, "title": "Cell-of-origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B-cell lymphoma.", "authors": [{"family": "Abdulla", "given": "Maysaa", "initials": "M"}, {"family": "Hollander", "given": "Peter", "initials": "P", "orcid": "0000-0002-0226-5681", "researcher": {"href": "https://publications.scilifelab.se/researcher/b1c6693d3ede463eb78e6da010db601f.json"}}, {"family": "Pandzic", "given": "Tatjana", "initials": "T"}, {"family": "Mansouri", "given": "Larry", "initials": "L"}, {"family": "Ednersson", "given": "Susanne Bram", "initials": "SB"}, {"family": "Andersson", "given": "Per-Ola", "initials": "PO"}, {"family": "Hultdin", "given": "Magnus", "initials": "M"}, {"family": "Fors", "given": "Maja", "initials": "M"}, {"family": "Erlanson", "given": "Martin", "initials": "M"}, {"family": "Degerman", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2783-0712", "researcher": {"href": "https://publications.scilifelab.se/researcher/8611162e883645f59195c4221199967f.json"}}, {"family": "Petersen", "given": "Helga Munch", "initials": "HM"}, {"family": "Asmar", "given": "Fazila", "initials": "F"}, {"family": "Gr\u00f8nbaek", "given": "Kirsten", "initials": "K"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}, {"family": "Cavelier", "given": "Lucia", "initials": "L", "orcid": "0009-0003-8195-370X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f01226edb140436da0c9d166c1f5fe51.json"}}, {"family": "Rosenquist", "given": "Richard", "initials": "R", "orcid": "0000-0002-0211-8788", "researcher": {"href": "https://publications.scilifelab.se/researcher/b570128e641140fb964ae3241414f510.json"}}, {"family": "Amini", "given": "Rose-Marie", "initials": "RM", "orcid": "0000-0003-0901-5252", "researcher": {"href": "https://publications.scilifelab.se/researcher/c157abcd61fa4900b5ad502b408d6d95.json"}}], "type": "journal article", "published": "2020-01-00", "journal": {"volume": "95", "issn": "1096-8652", "issue": "1", "pages": "57-67", "title": "Am. J. Hematol.", "issn-l": "0361-8609"}, "abstract": "The tumor cells in diffuse large B-cell lymphomas (DLBCL) are considered to originate from germinal center derived B-cells (GCB) or activated B-cells (ABC). Gene expression profiling (GEP) is preferably used to determine the cell of origin (COO). However, GEP is not widely applied in clinical practice and consequently, several algorithms based on immunohistochemistry (IHC) have been developed. Our aim was to evaluate the concordance of COO assignment between the Lymph2Cx GEP assay and the IHC-based Hans algorithm, to decide which model is the best survival predictor. Both GEP and IHC were performed in 359 homogenously treated Swedish and Danish DLBCL patients, in a retrospective multicenter cohort. The overall concordance between GEP and IHC algorithm was 72%; GEP classified 85% of cases assigned as GCB by IHC, as GCB, while 58% classified as non-GCB by IHC, were categorized as ABC by GEP. There were significant survival differences (overall survival and progression-free survival) if cases were classified by GEP, whereas if cases were categorized by IHC only progression-free survival differed significantly. Importantly, patients assigned as non-GCB/ABC both by IHC and GEP had the worst prognosis, which was also significant in multivariate analyses. Double expression of MYC and BCL2 was more common in ABC cases and was associated with a dismal outcome. In conclusion, to determine COO both by IHC and GEP is the strongest outcome predictor to identify DLBCL patients with the worst outcome.", "doi": "10.1002/ajh.25666", "pmid": "31659781", "labels": {"Clinical Genomics Uppsala": "Collaborative", "Bioinformatics Support for Computational Resources": "Service", "Clinical Genomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC6916573"}], "notes": [], "created": "2019-11-29T13:25:33.461Z", "modified": "2024-01-16T13:48:43.178Z"}, {"entity": "publication", "iuid": "cb3714bba2054d88a6db98b25edb4c9c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/cb3714bba2054d88a6db98b25edb4c9c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/cb3714bba2054d88a6db98b25edb4c9c"}}, "title": "Next generation RNA-sequencing in prognostic subsets of chronic lymphocytic leukemia.", "authors": [{"family": "Mansouri", "given": "Larry", "initials": "L"}, {"family": "Gunnarsson", "given": "Rebeqa", "initials": "R"}, {"family": "Sutton", "given": "Lesley-Ann", "initials": "LA"}, {"family": "Ameur", "given": "Adam", "initials": "A", "orcid": "0000-0001-6085-6749", "researcher": {"href": "https://publications.scilifelab.se/researcher/e960811513664a78b2804a00ee70f7c3.json"}}, {"family": "Hooper", "given": "Sean D", "initials": "SD"}, {"family": "Mayrhofer", "given": "Markus", "initials": "M"}, {"family": "Juliusson", "given": "Gunnar", "initials": "G"}, {"family": "Isaksson", "given": "Anders", "initials": "A"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Rosenquist", "given": "Richard", "initials": "R"}], "type": "comparative study", "published": "2012-07-00", "journal": {"volume": "87", "issn": "1096-8652", "issue": "7", "pages": "737-740", "title": "Am. J. Hematol.", "issn-l": "0361-8609"}, "abstract": "Advances in next-generation RNA-sequencing have revealed the complexity of transcriptomes by allowing both coding and noncoding(nc)RNAs to be analyzed. However, limited data exist regarding the whole transcriptional landscape of chronic lymphocytic leukemia(CLL). In this pilot-study, we evaluated RNA-sequencing in CLL by comparing two subsets which carry almost identical or \"stereotyped\" B-cell receptors with distinct clinical outcome, that is the poor-prognostic subset #1 (n 5 4) and the more favorable-prognostic subset #4(n 5 4). Our analysis revealed that 156 genes (e.g. LPL, WNT9A) and 76 ncRNAs, (e.g. SNORD48, SNORD115) were differentially expressed between the subsets. This technology also enabled us to identify numerous subset-specific splice variants (n 5 406), which were predominantly expressed in subset #1, including a splice-isoform of MSI2 with a novel start exon. A further important application of RNA-sequencing was for mutation detection and revealed 16\u201330 missense mutations per sample; notably many of these changes were found in genes with a strong potential for involvement in CLL pathogenesis, e.g., ATM and NOTCH2.This study not only demonstrates the effectiveness of RNA-sequencing for identifying mutations, quantifying gene expression and detecting splicing events, but also highlights the potential such global approaches have to significantly advance our understanding of the molecular mechanisms behind CLL development.", "doi": "10.1002/ajh.23227", "pmid": "22674506", "labels": {"National Genomics Infrastructure": null, "Array and Analysis Facility": null, "NGI Uppsala (Uppsala Genome Center)": null}, "xrefs": [], "notes": [], "created": "2017-05-04T14:57:27.993Z", "modified": "2021-07-07T14:37:06.614Z"}, {"entity": "publication", "iuid": "b839da82b5ed42dfa4c08eb8f18be674", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b839da82b5ed42dfa4c08eb8f18be674.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b839da82b5ed42dfa4c08eb8f18be674"}}, "title": "Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia.", "authors": [{"family": "Halld\u00f3rsd\u00f3ttir", "given": "Anna Margr\u00e9t", "initials": "AM"}, {"family": "Kanduri", "given": "Meena", "initials": "M"}, {"family": "Marincevic", "given": "Millaray", "initials": "M"}, {"family": "Mansouri", "given": "Larry", "initials": "L"}, {"family": "Isaksson", "given": "Anders", "initials": "A"}, {"family": "G\u00f6ransson", "given": "Hanna", "initials": "H"}, {"family": "Axelsson", "given": "Tomas", "initials": "T"}, {"family": "Agarwal", "given": "Prasoon", "initials": "P"}, {"family": "Jernberg-Wiklund", "given": "Helena", "initials": "H"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K"}, {"family": "Sander", "given": "Birgitta", "initials": "B"}, {"family": "Ehrencrona", "given": "Hans", "initials": "H"}, {"family": "Rosenquist", "given": "Richard", "initials": "R"}], "type": "comparative study", "published": "2012-04-00", "journal": {"volume": "87", "issn": "1096-8652", "issue": "4", "pages": "361-367", "title": "Am. J. Hematol.", "issn-l": "0361-8609"}, "abstract": "Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) are mature CD5(+) B-cell malignancies with different biological/clinical characteristics. We recently reported an association between different prognostic subgroups of CLL (i.e., IGHV mutated and unmutated) and genomic methylation pattern. However, the relationship between DNA methylation and prognostic markers, such as the proliferation gene expression signature, has not been investigated in MCL. We applied high-resolution methylation microarrays (27,578 CpG sites) to assess the global DNA methylation profiles in 20 MCL (10 each with high/low proliferation signature) and 30 CLL (15 poor-prognostic IGHV unmutated subset #1 and 15 good-prognostic IGHV mutated subset #4) samples. Notably, MCL and each CLL subset displayed distinct genomic methylation profiles. After unsupervised hierarchical clustering, 17/20 MCL cases formed a cluster separate from CLL, while CLL subsets #1 and #4 formed subclusters. Surprisingly, few differentially methylated genes (n = 6) were identified between high vs. low proliferation MCL. In contrast, distinct methylation profiles were demonstrated for MCL and CLL. Importantly, certain functional classes of genes were preferentially methylated in either disease. For instance, developmental genes, in particular homeobox transcription factor genes (e.g., HLXB9, HOXA13), were more highly methylated in MCL, whereas apoptosis-related genes were enriched among targets methylated in CLL (e.g., CYFIP2, NR4A1). Results were validated using pyrosequencing, RQ-PCR and reexpression of specific genes. In summary, the methylation profile of MCL was homogeneous and no correlation with the proliferation signature was observed. Compared to CLL, however, marked differences were discovered such as the preferential methylation of homeobox genes in MCL.", "doi": "10.1002/ajh.23115", "pmid": "22374828", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null, "Array and Analysis Facility": null}, "xrefs": [], "notes": [], "created": "2017-05-04T15:00:52.258Z", "modified": "2020-01-21T13:56:04.843Z"}], "created": "2017-05-09T09:12:02.629Z", "modified": "2020-11-27T13:14:01.226Z"}