{"entity": "journal", "iuid": "f6a02514571c4c1d982cea9c40a68b2e", "timestamp": "2026-07-20T12:38:18.955Z", "links": {"self": {"href": "https://publications.scilifelab.se/journal/Adv%20Mater.json"}, "display": {"href": "https://publications.scilifelab.se/journal/Adv%20Mater"}}, "title": "Adv Mater", "issn": "1521-4095", "issn-l": null, "publications_count": 4, "publications": [{"entity": "publication", "iuid": "061cf4f28b2e40c1bc8944cd8c3e49eb", "links": {"self": {"href": "https://publications.scilifelab.se/publication/061cf4f28b2e40c1bc8944cd8c3e49eb.json"}, "display": {"href": "https://publications.scilifelab.se/publication/061cf4f28b2e40c1bc8944cd8c3e49eb"}}, "title": "Folding of mRNA-DNA Origami for Controlled Translation and Viral Vector Packaging.", "authors": [{"family": "Seitz", "given": "Iris", "initials": "I"}, {"family": "Saarinen", "given": "Sharon", "initials": "S"}, {"family": "Wierzchowiecka", "given": "Julia", "initials": "J"}, {"family": "Kumpula", "given": "Esa-Pekka", "initials": "EP"}, {"family": "Shen", "given": "Boxuan", "initials": "B"}, {"family": "Cornelissen", "given": "Jeroen J L M", "initials": "JJLM"}, {"family": "Linko", "given": "Veikko", "initials": "V"}, {"family": "Huiskonen", "given": "Juha T", "initials": "JT"}, {"family": "Kostiainen", "given": "Mauri A", "initials": "MA", "orcid": "0000-0002-8282-2379", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ee9e43163b14b22acdf3613dbd18d89.json"}}], "type": "journal article", "published": "2025-04-00", "journal": {"title": "Adv Mater", "issn": "1521-4095", "volume": "37", "issue": "15", "pages": "e2417642", "issn-l": null}, "abstract": "mRNA is an important molecule in vaccine development and treatment of genetic disorders. Its capability to hybridize with DNA oligonucleotides in a programmable manner facilitates the formation of RNA-DNA origami structures, which can possess a well-defined morphology and serve as rigid supports for mRNA delivery. However, to date, comprehensive studies on the requirements for efficient folding of mRNA into distinct mRNA-DNA structures while preserving its translation functionality remain elusive. Here, the impact of design parameters on the folding of protein-encoding mRNA into mRNA-DNA origami structures is systematically investigated and the importance of the availability of ribosome-binding sequences on the translation efficiency is demonstrated. Furthermore, these hybrid structures are encapsulated inside virus capsids resulting in protecting them against nuclease degradation and also in enhancement of their cellular uptake. This multicomponent system therefore showcases a modular and versatile nanocarrier. The work provides valuable insight into the design of mRNA-DNA origami structures contributing to the development of mRNA-based gene delivery platforms.", "doi": "10.1002/adma.202417642", "pmid": "40012449", "labels": {"Cryo-EM": "Service"}, "xrefs": [], "notes": [], "created": "2025-11-13T09:37:43.422Z", "modified": "2025-11-13T09:37:43.506Z"}, {"entity": "publication", "iuid": "93a57112d58d4b2593e10c559050f75b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/93a57112d58d4b2593e10c559050f75b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/93a57112d58d4b2593e10c559050f75b"}}, "title": "A Room-Temperature Spin-Valve with van der Waals Ferromagnet Fe5 GeTe2 /Graphene Heterostructure.", "authors": [{"family": "Zhao", "given": "Bing", "initials": "B", "orcid": "0000-0002-5560-6750", "researcher": {"href": "https://publications.scilifelab.se/researcher/22329dc812fc4684acce02c18ae6fa18.json"}}, {"family": "Ngaloy", "given": "Roselle", "initials": "R"}, {"family": "Ghosh", "given": "Sukanya", "initials": "S"}, {"family": "Ershadrad", "given": "Soheil", "initials": "S"}, {"family": "Gupta", "given": "Rahul", "initials": "R"}, {"family": "Ali", "given": "Khadiza", "initials": "K"}, {"family": "Hoque", "given": "Anamul Md", "initials": "AM"}, {"family": "Karpiak", "given": "Bogdan", "initials": "B"}, {"family": "Khokhriakov", "given": "Dmitrii", "initials": "D"}, {"family": "Polley", "given": "Craig", "initials": "C"}, {"family": "Thiagarajan", "given": "Balasubramanian", "initials": "B"}, {"family": "Kalaboukhov", "given": "Alexei", "initials": "A"}, {"family": "Svedlindh", "given": "Peter", "initials": "P"}, {"family": "Sanyal", "given": "Biplab", "initials": "B"}, {"family": "Dash", "given": "Saroj P", "initials": "SP", "orcid": "0000-0001-7931-4843", "researcher": {"href": "https://publications.scilifelab.se/researcher/85c1dc56dd6a433c8ac7a5420d0c3af0.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Adv Mater", "issn": "1521-4095", "volume": "35", "issue": "16", "pages": "e2209113", "issn-l": null}, "abstract": "The discovery of van der Waals (vdW) magnets opened a new paradigm for condensed matter physics and spintronic technologies. However, the operations of active spintronic devices with vdW ferromagnets are limited to cryogenic temperatures, inhibiting their broader practical applications. Here, the robust room-temperature operation of lateral spin-valve devices using the vdW itinerant ferromagnet Fe5 GeTe2 in heterostructures with graphene is demonstrated. The room-temperature spintronic properties of Fe5 GeTe2 are measured at the interface with graphene with a negative spin polarization. Lateral spin-valve and spin-precession measurements provide unique insights by probing the Fe5 GeTe2 /graphene interface spintronic properties via spin-dynamics measurements, revealing multidirectional spin polarization. Density functional theory calculations in conjunction with Monte Carlo simulations reveal significantly canted Fe magnetic moments in Fe5 GeTe2 along with the presence of negative spin polarization at the Fe5 GeTe2 /graphene interface. These findings open opportunities for vdW interface design and applications of vdW-magnet-based spintronic devices at ambient temperatures.", "doi": "10.1002/adma.202209113", "pmid": "36641649", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-27T21:41:14.903Z", "modified": "2024-01-16T13:48:33.745Z"}, {"entity": "publication", "iuid": "6d4a622470314113a2e69dc4797c1cd2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6d4a622470314113a2e69dc4797c1cd2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6d4a622470314113a2e69dc4797c1cd2"}}, "title": "Coupling Lipid Nanoparticle Structure and Automated Single Particle Composition Analysis to Design Phospholipase Responsive Nanocarriers.", "authors": [{"family": "Barriga", "given": "Hanna M G", "initials": "HMG", "orcid": "0000-0002-2530-5332", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4bb3736c5e843018c6d245c0a584ece.json"}}, {"family": "Pence", "given": "Isaac J", "initials": "IJ", "orcid": "0000-0002-5635-1374", "researcher": {"href": "https://publications.scilifelab.se/researcher/87335a69752342798f15de8174337a3d.json"}}, {"family": "Holme", "given": "Margaret N", "initials": "MN", "orcid": "0000-0002-7314-9493", "researcher": {"href": "https://publications.scilifelab.se/researcher/33c5e475e13343eeabbc47c81c238e41.json"}}, {"family": "Doutch", "given": "James J", "initials": "JJ", "orcid": "0000-0003-0747-8368", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e1b2f6a54554068b76215bdc2554b61.json"}}, {"family": "Penders", "given": "Jelle", "initials": "J", "orcid": "0000-0002-5232-917X", "researcher": {"href": "https://publications.scilifelab.se/researcher/6b4d1a5b63934ad1876d4615f944bf5d.json"}}, {"family": "Nele", "given": "Valeria", "initials": "V", "orcid": "0000-0002-7263-7209", "researcher": {"href": "https://publications.scilifelab.se/researcher/dee5a93c05ea42ae853437cfe22d9383.json"}}, {"family": "Thomas", "given": "Michael R", "initials": "MR", "orcid": "0000-0001-7795-9648", "researcher": {"href": "https://publications.scilifelab.se/researcher/c898ca728237445a8ee4c7e6e5b053bc.json"}}, {"family": "Carroni", "given": "Marta", "initials": "M", "orcid": "0000-0002-7697-6427", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7f1bc1767024368abcb11a83184994a.json"}}, {"family": "Stevens", "given": "Molly M", "initials": "MM", "orcid": "0000-0002-1146-7090", "researcher": {"href": "https://publications.scilifelab.se/researcher/11363a4ab6a749e69fbb0876b52a0060.json"}}], "type": "journal article", "published": "2022-03-31", "journal": {"title": "Adv Mater", "issn": "1521-4095", "pages": "e2200839", "issn-l": null}, "abstract": "Lipid nanoparticles (LNPs) are versatile structures with tunable physicochemical properties that are ideally suited as a platform for vaccine delivery and RNA therapeutics. A key barrier to LNP rational design is the inability to relate composition and structure to intracellular processing and function. Here we combine Single Particle Automated Raman Trapping Analysis (SPARTA\u00ae ) with small angle scattering (SAXS / SANS) techniques to link LNP composition with internal structure and morphology and to monitor dynamic LNP - phospholipase D (PLD) interactions. Our analysis demonstrates that phospholipase D, a key intracellular trafficking mediator, can access the entire LNP lipid membrane to generate stable, anionic LNPs. PLD activity on vesicles with matched amounts of enzyme substrate was an order of magnitude lower, indicating that the LNP lipid membrane structure can be used to control enzyme interactions. This represents an opportunity to design enzyme-responsive LNP solutions for stimuli-responsive delivery and diseases where PLD is dysregulated. This article is protected by copyright. All rights reserved.", "doi": "10.1002/adma.202200839", "pmid": "35358374", "labels": {"Cryo-EM": "Collaborative"}, "xrefs": [], "notes": [], "created": "2022-04-08T16:00:50.365Z", "modified": "2022-04-08T16:00:50.677Z"}, {"entity": "publication", "iuid": "28fbca31a083484e900428034205c04c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/28fbca31a083484e900428034205c04c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/28fbca31a083484e900428034205c04c"}}, "title": "3D Microvascularized Tissue Models by Laser-Based Cavitation Molding of Collagen.", "authors": [{"family": "Enrico", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-8821-6759", "researcher": {"href": "https://publications.scilifelab.se/researcher/b30502c4fa3449cc9c24beb008784119.json"}}, {"family": "Voulgaris", "given": "Dimitrios", "initials": "D", "orcid": "0000-0003-4574-1702", "researcher": {"href": "https://publications.scilifelab.se/researcher/cbe852335b244342ba06b855e4135205.json"}}, {"family": "\u00d6stmans", "given": "Rebecca", "initials": "R"}, {"family": "Sundaravadivel", "given": "Naveen", "initials": "N"}, {"family": "Moutaux", "given": "Lucille", "initials": "L"}, {"family": "Cordier", "given": "Aur\u00e9lie", "initials": "A"}, {"family": "Niklaus", "given": "Frank", "initials": "F", "orcid": "0000-0002-0525-8647", "researcher": {"href": "https://publications.scilifelab.se/researcher/b001b91a6d9a4ec0aafb93bdd5e3be17.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications.scilifelab.se/researcher/a9d4508938be49ddabacb3a1f39969d4.json"}}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-9552-4234", "researcher": {"href": "https://publications.scilifelab.se/researcher/446ac390fcad4ced98cd8d7c89e1d4da.json"}}], "type": "journal article", "published": "2022-01-14", "journal": {"title": "Adv Mater", "issn": "1521-4095", "pages": "e2109823", "issn-l": null}, "abstract": "3D tissue models recapitulating human physiology are important for fundamental biomedical research, and they hold promise to become a new tool in drug development. An integrated and defined microvasculature in 3D tissue models is necessary for optimal cell functions. However, conventional bioprinting only allows the fabrication of hydrogel scaffolds containing vessel-like structures with large diameters (>100 \u00b5m) and simple geometries. Recent developments in laser photoablation enable the generation of this type of structure with higher resolution and complexity, but the photo-thermal process can compromise cell viability and hydrogel integrity. To address these limitations, the present work reports in situ 3D patterning of collagen hydrogels by femtosecond laser irradiation to create channels and cavities with diameters ranging from 20 to 60 \u00b5m. In this process, laser irradiation of the hydrogel generates cavitation gas bubbles that rearrange the collagen fibers, thereby creating stable microchannels. Such 3D channels can be formed in cell- and organoid-laden hydrogel without affecting the viability outside the lumen and can enable the formation of artificial microvasculature by the culture of endothelial cells and cell media perfusion. Thus, this method enables organs-on-a-chip and 3D tissue models featuring complex microvasculature.", "doi": "10.1002/adma.202109823", "pmid": "35029309", "labels": {"Integrated Microscopy Technologies Stockholm": "Service"}, "xrefs": [], "notes": [], "created": "2022-02-16T15:24:31.224Z", "modified": "2022-02-16T15:24:31.439Z"}], "created": "2022-02-16T15:24:31.429Z", "modified": "2022-02-16T15:24:31.429Z"}